Progesterone

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INFORMATIONAL GUIDE PROGESTERONE METABOLITES PREMENOPAUSE Urinary Progesterone Metabolites in Premenopausal Women Not Supplementing with Progesterone

The urinary progestogen metabolites included in our profiles encompass the primary urinary metabolite, pregnanediol (Pgdiol), and four other more minor metabolites that belong to the pregnane (Allopregnanolone, Allo-pregnanediol) and pregnene (3α-dihydroprogesterone, 20α-dihydroprogesterone) categories. In postmenopausal women the level of pregnanediol is expected to be much lower than in preme...

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Progesterone regulation of the progesterone receptor in rat gonadotropes.

For rat pituitary cells, progesterone receptor (PR) protein localizes to gonadotropes and PR messenger RNA is induced by E2 and rapidly but transiently down-regulated by progesterone. Here we quantitatively establish the down-regulatory effect of progesterone on PR protein and evaluate possible mechanisms. Nuclear PR-immunoreactivity (PR-IR) in gonadotropes, identified by dual immunofluorescenc...

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Progesterone antagonists and progesterone receptor modulators: an overview.

Since the original description of the structure of the antiprogestin, mifepristone, was published, numerous related compounds have been synthesized which may function as progesterone antagonists (PAs) or progesterone receptor modulators (PRMs). The latter are mixed agonists-antagonists. Both PAs and PRMs have therapeutic applications in female health care. Mifepristone is predominantly a PA and...

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Progesterone and progesterone receptors in experimental breast cancer.

in ER-positive tumors would indicate that the tumor is capa ble of synthesizing at least 1 end product under estrogen regulation and may therefore be endocrine responsive (8). Although the hypothesis assumes that PGR levels in breast tumors, like those in the uterus, are under estrogen control, this priming effect has never been demonstrated. In this paper we show that PGR in the DMBA-induced m...

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Induction of Lactation in Holstein Cows Using Progesterone Injections or Progesterone Vaginal Inserts

The aim of this study was to evaluate the effect of replacing progesterone injections by progesterone vaginal inserts on productive and reproductive parameters of lactating cows with reproductive problems after prolonged periods of heat stress. Fifteen Holstein cows were randomly assigned to one of three treatments: 1) treated with two progesterone vaginal inserts (P4-INS); 2) treated with prog...

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ژورنال

عنوان ژورنال: Climacteric

سال: 2018

ISSN: 1369-7137,1473-0804

DOI: 10.1080/13697137.2018.1462910